Significant linkage disequilibrium between the Huntington disease gene and the loci D4S10 and D4S95 in the Dutch population

Journal Article · Thu Oct 01 04:00:00 EDT 1992 · American Journal of Human Genetics; (United States)

OSTI ID:5053473

Skraastad, M I; Van de Vosse, E; Belfroid, R; Hoeld, K; Vegter-van der Vlis, M; Bakker, E; van Ommen, G J.B. ^[1]; Sandkuijl, L A ^[2]

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1. Leiden Univ. (Netherlands)
2. Univ. Hospital Kijkzigt, Rotterdam (Netherlands)

Significant linkage disequilibrium has been found between the Huntington disease (HD) gene and DNA markers located around D4S95 and D4S98. The linkage-disequilibrium studies favor the proximal location of the HD gene, in contrast to the conflicting results of recombination analyses. The authors have analyzed 45 Dutch HD families with 19 DNA markers and have calculated the strength of linkage disequilibrium. Highly significant linkage disequilibrium has been detected with D4S95, consistent with the studies in other populations. In contrast with most other studies, however, the area of linkage disequilibrium extends from D4S10 proximally to D4S95, covering 1,100 kb. These results confirm that the HD gene most likely maps near D4S95. 28 refs., 1 fig., 2 tabs.

• OSTI ID: 5053473
• Journal Information: American Journal of Human Genetics; (United States), Journal Name: American Journal of Human Genetics; (United States) Vol. 51:4; ISSN AJHGAG; ISSN 0002-9297
• Country of Publication: United States
• Language: English

Related Subjects

550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
BIOLOGICAL MARKERS
CHROMOSOMES
DISEASES
GENE MUTATIONS
GENETIC MAPPING
HUMAN CHROMOSOMES
MAPPING
MUTATIONS
NERVOUS SYSTEM DISEASES