Regulation of hemopoiesis: inhibitors and stimulators produced by a murine bone marrow stromal cell line (H-1)

Conference · Fri Jan 01 00:00:00 EST 1982

OSTI ID:5049287

Cronkite, E P; Miller, M E; Garnett, H; Harigaya, K

A murine cell line (H-1) probably derived from the adventitial reticular cell has been isolated and preserved. This line produces: (1) CSF; (2) a labile inhibitor of CFU-c proliferation with preferential action on granulopoiesis; (3) PGE; (4) proliferation inhibitors of BFU-E and GEMM; and (5) suppression of entry of CFU-S into DNA synthesis in vitro. It is postulated that the adventitial reticular cell (ARC) may play a major regulatory role in hemopoiesis through intramedullary production of the factors described. The nature of the signals that activate the genes in the ARC which are coded for the factors described is not known.

• Research Organization: Brookhaven National Lab., Upton, NY (USA); University of the Witwatersrand, Johannesburg (South Africa). Dept. of Microbiology; Keio Univ., Tokyo (Japan). Dept. of Pathology
• DOE Contract Number: AC02-76CH00016
• OSTI ID: 5049287
• Report Number(s): BNL-31594; CONF-8206107-1; ON: DE82019980
• Resource Relation: Conference: 18. Alfred Benzon symposium - haemopoietic stem cells, Copenhagen, Denmark, 13 Jun 1982
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BLOOD FORMATION
INHIBITION
BONE MARROW CELLS
BIOLOGICAL EFFECTS
RADIOSENSITIVITY
CFU
CELL CULTURES
GENETICS
MICE
SOMATIC CELLS
ANIMAL CELLS
ANIMALS
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CONNECTIVE TISSUE CELLS
MAMMALS
RODENTS
VERTEBRATES
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550300 - Cytology
560121 - Radiation Effects on Cells- External Source- (-1987)