Comparison of adjuvant postoperative radiotherapy and multiple-drug chemotherapy (CMF-VP) in operable breast cancer patients with more than four positive axillary lymph nodes

Journal Article · Thu Jul 15 04:00:00 EDT 1982 · Cancer (Philadelphia); (United States)

DOI:https://doi.org/10.1002/1097-0142(19820715)50:2<212::AID-CNCR2820500208>3.0.CO;2-V· OSTI ID:5048482

Chu, A M ^[1]; Kiel, K

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1. Univ. of Louisville, KY

With the advent of adjuvant chemotherapy in 1974 for early operable breast cancer at Massachusetts General Hospital, 41 patients with GAMMAreater than or equal to 4 lymph nodes positive in their axillary dissection received a two-year course of the modified Cooper regimen (S + CH) between March 1974 and June 1976. The actuarial disease-free survival was found to be comparable to CMF as reported by Bonnadonna. No consistent randomization with a control group was possible. Since postoperative radiotherapy has been proven to decrease the incidence of local recurrence but does not affect survival, it was believed that this group should serve as an adequate control. Sixty patients with GAMMAreater than or equal to 4 positive axillary lymph nodes in their axillary dissection who were given postoperative radiotherapy to the chest wall and draining lymphatics (S + RT) in 1973 and 1974 at the same institution were retrospectively analyzed and compared to the above group. Relatively little significant difference in survival and disease-free survival curves was found. At 48 months, there was 72% and 58% survival for the S + RT and S + CH groups, respectively. When subgrouped according to age, those patients <49-years-old had a 48-month disease-free survival of 65% and 49% for S + RT and S + CH groups, respectively (P=0.25). No significant difference was noted in the post menopausal group. In both groups, patients with >50% positive axillary lymph nodes exhibited a poor prognosis.

• OSTI ID: 5048482
• Journal Information: Cancer (Philadelphia); (United States), Journal Name: Cancer (Philadelphia); (United States) Vol. 50:2; ISSN CANCA
• Country of Publication: United States
• Language: English

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550600 -- Medicine
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62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CHEMOTHERAPY
COBALT 60
COBALT ISOTOPES
DISEASES
FRACTIONATED IRRADIATION
GLANDS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LUNGS
LYMPH NODES
LYMPHATIC SYSTEM
MAMMARY GLANDS
MEDICINE
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
ORGANS
PATIENTS
RADIATION EFFECTS
RADIOISOTOPES
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOTHERAPY
RESPIRATORY SYSTEM
SIDE EFFECTS
SKIN
SURVIVAL CURVES
SURVIVAL TIME
THERAPY
YEARS LIVING RADIOISOTOPES