Bence Jones Proteins: A powerful tool for the fundamental study of protein chemistry and pathophysiology

Journal Article · Tue Jul 16 00:00:00 EDT 1991 · Biochemistry; (United States)

DOI:https://doi.org/10.1021/bi00242a001· OSTI ID:5047479

Stevens, F J; Schiffer, M ^[1]; Solomon, A ^[2]

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1. Argonne National Lab., IL (United States)
2. Univ of Tennessee Medical Center/Graduate School of Medicine, Knoxville (United States)

This review article discusses the biochemistry, variability in structure and clinical significance of understanding the mechanism of Bence Jones proteins. Continued research on these proteins provides will provide new insights into the pathogenesis of human light-chain-associated renal and systemic diseases. Research studies have contributed to an understanding of the molecular basis of protein structure and interaction, to protein engineering, and to design of protein-specific synthetic drugs.

• OSTI ID: 5047479
• Journal Information: Biochemistry; (United States), Vol. 30:28; ISSN 0006-2960
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
IMMUNE SYSTEM DISEASES
PHYSIOLOGY
PROTEINS
BIOCHEMISTRY
AMINO ACID SEQUENCE
DIMERIZATION
PATIENTS
TUBULES
URINE
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
CHEMICAL REACTIONS
CHEMISTRY
DISEASES
KIDNEYS
MATERIALS
MOLECULAR STRUCTURE
ORGANIC COMPOUNDS
ORGANS
POLYMERIZATION
WASTES
550200* - Biochemistry