Dysprosium-165 ferric hydroxide macroaggregates for radiation synovectomy. [Rabbits]

Journal Article · Wed Mar 01 04:00:00 EST 1978 · J. Nucl. Med.; (United States)

OSTI ID:5045140

Hnatowich, D J; Kramer, R I; Sledge, C B; Noble, J; Shortkroff, S

Radiation synovectomy of the knee has been performed previously with colloidal-sized particles containing long-lived radionuclides such as yttrium-90 and gold-198. Although the majority of patients respond well, a significant problem has been the leakage of radioactive material from the knee. We have improved the procedure by using larger particles to minimize leakage and a radionuclide with a shorter physical half-life, so that only leakage occurring soon after administration contributes to radiation exposure. The particles are ferric hydroxide macroaggregates with a size range of 0.5 to 5 ..mu..m, labeled by coprecipitation with dysprosium-165. This radioisotope is a short-lived (T/sub 1/2/ = 139 min) beta emitter, which may be produced at high specific activity by reactor irradiation of natural dysprosium. We have studied the particles in both normal and arthritic rabbits. The leakage following injection of the macroaggregates into the knee has been found to be lower than that for gold colloid in the same animal model. At 24 hr, the accumulation is about 0.3 percent of dose in the liver, the major site of uptake, about 0.1 percent in the kidneys, and considerably less in other tissues. Because of the low leakage rates and the use of a short-lived radionuclide, it may be estimated that a patient's whole-body exposure due to therapy of a knee with this technique will be about 0.4 rads to the whole body and about 2 rads to the liver.

• Research Organization: Massachusetts Inst. of Tech., Cambridge
• OSTI ID: 5045140
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 19:3; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BONE JOINTS
DISEASES
DYSPROSIUM 165
DYSPROSIUM ISOTOPES
EVEN-ODD NUCLEI
HYDROGEN COMPOUNDS
HYDROXIDES
INTERMEDIATE MASS NUCLEI
IRON COMPOUNDS
IRON HYDROXIDES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ORGANS
OXYGEN COMPOUNDS
PARTICLE SIZE
PARTICLES
PATIENTS
RABBITS
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RARE EARTH ISOTOPES
RARE EARTH NUCLEI
RHEUMATIC DISEASES
SIZE
SKELETAL DISEASES
SKELETON
SURGERY
THERAPY
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES