Computer Assisted Tomography of focal cerebral radiation necrosis in the monkey. [X radiation]

Journal Article · Tue Nov 01 04:00:00 EST 1977 · J. Neuropathol. Exp. Neurol.; (United States)

DOI:https://doi.org/10.1097/00005072-197711000-00006· OSTI ID:5043142

O'Neill, R R; Wakisaka, S; Malamut, B L

The right occipital lobe in a series of pubescent monkeys was exposed to 3500 rads of orthovoltage radiation in a single dose. Sixteen to 38 weeks later the irradiated region broke down, rather abruptly. The visual evoked response, funduscopic photography, cerebral spinal fluid determinations for protein and lactic dehydrogenase, and computer assisted tomography (CAT) were used to anticipate and reflect the breakdown in neural tissue. CAT scanning demonstrated the two main effects of focal delayed radiation necrosis in this model (in a representative monkey): pronounced vasogenic edema from a break in the blood brain barrier, and contralateral hydrocephalus from brain distortion with obstruction of cerebral spinal fluid circulation. These findings were confirmed by postmortem examinations.

• Research Organization: National Inst. of Neurological and Communicative Disorders and Stroke, Bethesda, MD
• OSTI ID: 5043142
• Journal Information: J. Neuropathol. Exp. Neurol.; (United States), Journal Name: J. Neuropathol. Exp. Neurol.; (United States) Vol. 36:6; ISSN JNENA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
COMPUTERS
DEHYDROGENASES
DISEASES
ELECTROMAGNETIC RADIATION
ENZYMES
IONIZING RADIATIONS
LACTATE DEHYDROGENASE
MAMMALS
MONKEYS
NECROSIS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
PATHOLOGICAL CHANGES
PRIMATES
PROTEINS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
TOMOGRAPHY
VERTEBRATES
X RADIATION