Early embryonic development in lead-intoxicated mice

Journal Article · Thu Dec 01 04:00:00 EST 1977 · Arch. Pathol. Lab. Med.; (United States)

OSTI ID:5042472

Jacquet, P

The development of the embryo until day 7 was studied in histologic sections of the uterus, oviduct, and ovary from normal and lead-treated mice (0.5% of lead in the diet). Such lead treatment causes a substantial reduction in pregnancies in successfully mated female mice. After lead treatment, the blastocyst is formed normally, although it has a slightly reduced size. Differentiation of giant cells in the trophoblast and of decidua cells in the uterus is, however, impaired. Moreover, the corpora lutea are underdeveloped. Since earlier normal estradiol secretion on day 4 and administered progesterone secretion from day 5 on had been found, activation of the embryo and/or development of decidua cells fall due to the absence of this hormone.

• Research Organization: Laboratoire de Genetique, Mol, Belgium
• OSTI ID: 5042472
• Journal Information: Arch. Pathol. Lab. Med.; (United States), Journal Name: Arch. Pathol. Lab. Med.; (United States) Vol. 101:12; ISSN APLMA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BODY
DIET
DISEASES
ELEMENTS
EMBRYOS
FEMALE GENITALS
HORMONES
INGESTION
INHIBITION
INTAKE
KETONES
LEAD
MAMMALS
METALS
MICE
ONTOGENESIS
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PREGNANCY
PREGNANES
PROGESTERONE
RODENTS
SECRETION
STEROID HORMONES
STEROIDS
UTERUS
VERTEBRATES