Heparin releases heparan sulfate from the cell surface
Journal Article
·
· Biochem. Biophys. Res. Commun.; (United States)
Heparan sulfate of the cell surface of cultured Chinese hamster cells (line CHO) was promptly released when the cells were incubated with balanced salt solutions containg heparin. The released heparan sulfate included multichain proteoglycan of high molecular weight. The data suggest that the cell-surface localization of heparan sulfate is dependent, at least in part, upon cell-surface receptors with binding sites for the sugar chain moieties of sulfated glycosaminoglycans.
- Research Organization:
- Los Alamos Scientific Lab., NM
- OSTI ID:
- 5039568
- Journal Information:
- Biochem. Biophys. Res. Commun.; (United States), Journal Name: Biochem. Biophys. Res. Commun.; (United States) Vol. 78:4; ISSN BBRCA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550200 -- Biochemistry
550300* -- Cytology
59 BASIC BIOLOGICAL SCIENCES
AMINES
ANIMAL CELLS
ANIMALS
ANTICOAGULANTS
BIOCHEMICAL REACTION KINETICS
BIOCHEMISTRY
BODY
CARBOHYDRATES
CELL CULTURES
CHEMICAL BONDS
CHEMICAL REACTIONS
CHEMISTRY
DIGESTIVE SYSTEM
DRUGS
GLANDS
HAMSTERS
HEPARIN
KINETICS
LIVER
MAMMALS
METABOLISM
MUCOPOLYSACCHARIDES
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PHYSIOLOGY
POLYSACCHARIDES
REACTION KINETICS
RODENTS
SACCHARIDES
SULFATES
SULFUR COMPOUNDS
VERTEBRATES
550300* -- Cytology
59 BASIC BIOLOGICAL SCIENCES
AMINES
ANIMAL CELLS
ANIMALS
ANTICOAGULANTS
BIOCHEMICAL REACTION KINETICS
BIOCHEMISTRY
BODY
CARBOHYDRATES
CELL CULTURES
CHEMICAL BONDS
CHEMICAL REACTIONS
CHEMISTRY
DIGESTIVE SYSTEM
DRUGS
GLANDS
HAMSTERS
HEPARIN
KINETICS
LIVER
MAMMALS
METABOLISM
MUCOPOLYSACCHARIDES
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PHYSIOLOGY
POLYSACCHARIDES
REACTION KINETICS
RODENTS
SACCHARIDES
SULFATES
SULFUR COMPOUNDS
VERTEBRATES