Selective postoperative radioactive iodine treatment of thyroid carcinoma

Journal Article · Fri Dec 01 04:00:00 EST 1989 · Surgery; (USA)

OSTI ID:5026830

McHenry, C; Jarosz, H; Davis, M; Barbato, A L; Lawrence, A M; Paloyan, E ^[1]

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1. Loyola Univ., Stritch School of Medicine, Maywood, IL (USA)

In a consecutive series of 234 patients with differentiated thyroid carcinoma of follicular cell origin (Huerthle cell tumors excluded), a radioactive iodine ({sup 131}I) scan was obtained 3 to 6 months after thyroidectomy and 4 weeks after cessation of thyroid hormone treatments, only if extrathyroidal tumor extension or nodal or distant metastases were present. Twenty-one patients (9%) with {sup 131}I uptake of 3% or more (group 1) were treated with 150 to 200 mCi of {sup 131}I. Forty-four patients (19%) with less than 3% uptake (group 2) and 169 patients (72%) without evidence of metastases or extrathyroidal spread (group 3) were treated only with thyroid hormone. All patients initially underwent total thyroidectomy and modified neck dissection if cervical lymph node metastases were present. Three patients in group 1 and one patient in group 2 had recurrent tumor with a mean follow-up of 8.9 and 8.4 years. There were no recurrences in group 3 with a mean follow-up of 7.2 years. Death rate from thyroid carcinoma was 5% in group 1 (one patient) and 0% in groups 2 and 3. In conclusion, {sup 131}I scanning and therapy may be omitted in patients with differentiated thyroid carcinoma in the absence of local tumor extension or regional or distant metastases. Therapy with {sup 131}I is not demonstrated to be of benefit in this population of patients.

• OSTI ID: 5026830
• Journal Information: Surgery; (USA), Journal Name: Surgery; (USA) Vol. 106:6; ISSN 0039-6060; ISSN SURGA
• Country of Publication: United States
• Language: English

Related Subjects

550604* -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARCINOMAS
DAYS LIVING RADIOISOTOPES
DISEASES
ENDOCRINE GLANDS
GLANDS
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOTOPES
LYMPH NODES
LYMPHATIC SYSTEM
MEDICINE
METASTASES
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATIENTS
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
SURGERY
SURVIVAL CURVES
THERAPY
THYROID
THYROIDECTOMY
UPTAKE