Development of a biological screening method to detect potential exposure of synfuel plant workers to carcinogenic substances. Final report
Technical Report
·
OSTI ID:5025361
The purpose of this project was to determine the feasibility of using the Ames assay as a biological monitoring tool to evaluate exposure to mutagens/carcinogens, which may be possibly generated by a synfuel plant. Phase I of this project consisted of analyzing urine samples of cigarette smokers and non-smokers for mutagenicity in order to establish that this assay can reproducibly detect mutagens present in smokers' urine, as well as to distinguish smoking-related mutagenic urine samples from work-related ones. This was necessary to develop a standardized protocal for urine screening. Phase II consisted of an extension of Phase I to examine mutagen activity as cake-oven workers, exposed to known carcinogens and known to have increased cancer risks. Phase II consisted of an analysis of mutagenic activity in urine samples from volunteer workers at the H-coal pilot plant at Catlettsburg, Ky.
- Research Organization:
- Kentucky Dept. of Energy, Lexington (USA)
- OSTI ID:
- 5025361
- Report Number(s):
- PB-82-192709
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
01 COAL, LIGNITE, AND PEAT
016000 -- Coal
Lignite
& Peat-- Health & Safety
500200 -- Environment
Atmospheric-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BACTERIA
BIOASSAY
BIOLOGICAL INDICATORS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CARCINOGEN SCREENING
CARCINOGENS
DETECTION
DISEASES
FEASIBILITY STUDIES
FEDERAL REGION IV
HAZARDOUS MATERIALS
INDUSTRIAL PLANTS
KENTUCKY
MATERIALS
MICROORGANISMS
MUTAGEN SCREENING
MUTAGENS
NEOPLASMS
NORTH AMERICA
PERSONNEL
SALMONELLA
SCREENING
SYNTHETIC FUELS REFINERIES
URINE
USA
WASTES
016000 -- Coal
Lignite
& Peat-- Health & Safety
500200 -- Environment
Atmospheric-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BACTERIA
BIOASSAY
BIOLOGICAL INDICATORS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CARCINOGEN SCREENING
CARCINOGENS
DETECTION
DISEASES
FEASIBILITY STUDIES
FEDERAL REGION IV
HAZARDOUS MATERIALS
INDUSTRIAL PLANTS
KENTUCKY
MATERIALS
MICROORGANISMS
MUTAGEN SCREENING
MUTAGENS
NEOPLASMS
NORTH AMERICA
PERSONNEL
SALMONELLA
SCREENING
SYNTHETIC FUELS REFINERIES
URINE
USA
WASTES