Kinetics of rubidium-82 after coronary occlusion and reperfusion. Assessment of patency and viability in open-chested dogs

Journal Article · Mon Apr 01 04:00:00 EST 1985 · J. Clin. Invest.; (United States)

DOI:https://doi.org/10.1172/JCI111807· OSTI ID:5022068

Goldstein, R A

Currently available noninvasive techniques are unable to rapidly assess artery patency and tissue viability during acute myocardial infarction. In prior studies, rubidium-82 (Rb-82), a short-lived positron emitter obtained from a generator, was validated as an indicator of flow with a model that included the rate constants for transfer into and out of the cell. Accordingly, in the current study, 20 open-chested dogs with experimental infarction were studied serially at base line, after coronary occlusion, and at reperfusion. Time-activity curves acquired with beta probes on the epicardial surface were used to measure flow and net transfer of rubidium. Flow decreased to 0.41 ml/min per gram during occlusion and increased to 2.73 ml/min per gram in potentially viable ischemic tissue, whereas flows were 0.32 during occlusion and 1.58 ml/min per gram in irreversibly injured tissue. The transfer rate constant for Rb-82, kT, did not change significantly during occlusion in viable vs. nonviable samples, except that 4 out of 11 nonviable tissue samples had negative KTs. At reperfusion, viable myocardial samples were all positive, whereas all irreversibly injured tissues had a negative kT. This study suggests that Rb-82 time-activity curves can be useful to determine patency of an infarct related artery and potential viability after reperfusion during myocardial infarction.

• Research Organization: Univ. of Texas Health Science Center, Houston
• OSTI ID: 5022068
• Journal Information: J. Clin. Invest.; (United States), Journal Name: J. Clin. Invest.; (United States) Vol. 4; ISSN JCINA
• Country of Publication: United States
• Language: English

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550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ALKALI METAL ISOTOPES
ANIMALS
ARTERIES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BLOOD FLOW
BLOOD VESSELS
BODY
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CARDIOVASCULAR SYSTEM
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DOGS
DYNAMIC FUNCTION STUDIES
ELECTRON CAPTURE RADIOISOTOPES
HEART
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MAMMALS
MINUTES LIVING RADIOISOTOPES
MYOCARDIAL INFARCTION
NUCLEI
ODD-ODD NUCLEI
ORGANS
RADIOISOTOPES
RADIONUCLIDE KINETICS
RUBIDIUM 82
RUBIDIUM ISOTOPES
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