In vitro histamine H/sub 2/-antagonist activity of the novel compound HUK 978

Journal Article · Mon Nov 04 00:00:00 EST 1985 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(85)90299-1· OSTI ID:5021833

Coombes, J D; Norris, D B; Rising, T J; Ross, B C; Steward, A

Histamine stimulated adenylate cyclase from guinea-pig fundic mucosa and /sup 3/H-tiotidine binding in guinea-pig cerebral cortex were used to assess the in-vitro histamine H/sub 2/-activity of the novel H/sub 2/-antagonist HUK 978. The results showed that HUK 978 was a more potent H/sub 2/-antagonist than either cimetidine or ranitidine. HUK 978 was also shown to be devoid of activity at the histamine H-/sub 1/-receptor, the muscarinic receptor and the ..cap alpha.. and ..beta..-adrenergic receptors.

• Research Organization: Hoechst Pharmaceutical Research Lab., Milton Keynes, England
• OSTI ID: 5021833
• Journal Information: Life Sci.; (United States), Vol. 37:18
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
CYCLASES
ENZYME ACTIVITY
HISTAMINE
CHEMICAL BONDS
RECEPTORS
CEREBRAL CORTEX
GUINEA PIGS
IN VITRO
TRACER TECHNIQUES
TRITIUM COMPOUNDS
AMINES
ANIMALS
AZOLES
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CEREBRUM
ENZYMES
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LYASES
MAMMALS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RODENTS
VERTEBRATES
550201* - Biochemistry- Tracer Techniques