Remyelination of demyelinated rat axons by transplanted mouse oligodendrocytes
- Department of Clinical Veterinary Medicine, University of Cambridge (England)
The injection of the gliotoxic agent ethidium bromide (EB) into spinal white matter produces a CNS lesion in which it is possible to investigate the ability of transplanted glial cells to reconstruct a glial environment around demyelinated axons. This study demonstrates that transplanted mouse glial cells can repopulate EB lesions in rats provided tissue rejection is controlled. In X-irradiated EB lesions in cyclosporin-A-treated rats, mouse oligodendrocytes remyelinated rat axons and, together with mouse astrocytes, re-established a CNS environment. When transplanted into nonirradiated EB lesions in nude rats, mouse glial cells modulated the normal host repair by Schwann cells to remyelination by oligodendrocytes. In both X-irradiated and non-irradiated EB lesions, transplanted mouse glial cells behaved similarly to isogenic rat glial cell transplants. These findings indicate that the cell-cell interactions involved in reconstruction of a glial environment are common to both mouse and rat.
- OSTI ID:
- 5018129
- Journal Information:
- Glia (New York); (United States), Vol. 4:3; ISSN 0894-1491
- Country of Publication:
- United States
- Language:
- English
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NERVE CELLS
BIOLOGICAL REPAIR
BIOLOGICAL RADIATION EFFECTS
CELL CULTURES
MICE
NERVOUS SYSTEM DISEASES
RATS
TRANSPLANTS
X RADIATION
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
DISEASES
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
MAMMALS
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RADIATIONS
RECOVERY
REPAIR
RODENTS
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560152* - Radiation Effects on Animals- Animals