Indium-111-labeled autologous leukocyte scanning in gastrointestinal graft versus host disease (GVHD)

Journal Article · Fri Aug 01 00:00:00 EDT 1986 · Dig. Dis. Sci.; (United States)

DOI:https://doi.org/10.1007/BF01296051· OSTI ID:5017697

Saverymuttu, S H; Peters, A M; O'Brien, C; Chadwick, V S; Lavender, J P; Goldman, J M; Gordon-Smith, E C; Hodgson, H J

The technique of scanning with indium-111 autologous leukocytes has been used to assess gastrointestinal graft-versus-host disease (GVHD) following allogenic marrow transplantation. In patients with active disease, abdominal scans showed extensive abnormal localization in the bowel, while in those whose disease was quiescent after responding to treatment, scans showed localized ileocecal involvement. Rectal histology showed excellent agreement with scanning in the diagnosis of GVHD, but in three of six cases with active disease underestimated disease severity. Indium-111 leukocyte scanning is a useful noninvasive technique for the diagnosis and assessment of gut GVHD.

• Research Organization: Hammersmith Hospital, London, England
• OSTI ID: 5017697
• Journal Information: Dig. Dis. Sci.; (United States), Journal Name: Dig. Dis. Sci.; (United States) Vol. 8; ISSN DDSCD
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL TISSUES
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIGESTIVE SYSTEM
ELECTRON CAPTURE RADIOISOTOPES
GASTROINTESTINAL TRACT
GRAFT-HOST REACTION
HEMATOPOIETIC SYSTEM
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LEUKOCYTES
MATERIALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATIENTS
RADIOISOTOPE SCANNING
RADIOISOTOPES
TISSUES
TRANSPLANTS