Effects of ionizing radiation in cocrystals of DNA model compounds: ESR-ENDOR studies of X-irradiated imidazole:barbital and adenosine:5-bromouracil

Thesis/Dissertation · Fri Jan 01 04:00:00 EST 1982

OSTI ID:5017675

Kar, L

Electron spin resonance (ESR) and electron nuclear double resonance (ENDOR) techniques have been used to study radiation induced damage in cocrystalline complexes X-irradiated at 12 K. The study addresses the following questions: (1) whether radiation induced damage is stabilized preferentially on one of the components of the cocrystalline system; and (2) whether charge transfer occurs between purine and pyrimidine bases in hydrogen bonded or stacked configurations. The cocrystals used in this study are imidazole:5,5-diethylbarbituric acid (barbital) and adenosine:5-bromouracil (AR:BU). Results indicate that (1) preferential stability of radiation damage may be observed in a cocrystal even in the absence of stacking interactions; (2) in the presence of purine:pyrimidine stacking electron transfer may occur, but hole transfer is not likely to be the mechanism of redistribution of radiation damage in cocrystalline systems. The radiation chemistry of AR:BU is used as a model to predict the effects of ionizing radiation on DNA.

• Research Organization: Rochester Univ., NY (USA)
• OSTI ID: 5017675
• Country of Publication: United States
• Language: English

Related Subjects

560111* -- Radiation Effects on Biochemicals-- In Vitro-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADDUCTS
ADENOSINE
ANESTHETICS
ANTIMETABOLITES
AROMATICS
AZAARENES
AZINES
AZOLES
BARBITURATES
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
BIOLOGICAL PATHWAYS
BIOLOGICAL RADIATION EFFECTS
BROMOURACILS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CHEMICAL RADIATION EFFECTS
CHEMISTRY
CRYSTAL STRUCTURE
DATA
DNA
DOUBLE RESONANCE METHODS
DRUGS
ELECTROMAGNETIC RADIATION
ELECTRON SPIN RESONANCE
EXPERIMENTAL DATA
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
HYPNOTICS AND SEDATIVES
IMIDAZOLES
INFORMATION
INJURIES
IONIZING RADIATIONS
MAGNETIC RESONANCE
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
NUMERICAL DATA
ORGANIC BROMINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PURINES
PYRIMIDINES
RADIATION CHEMISTRY
RADIATION EFFECTS
RADIATION INJURIES
RADIATIONS
RADICALS
RESONANCE
RIBOSIDES
STABILIZATION
STRUCTURAL CHEMICAL ANALYSIS
URACILS
X RADIATION