Effect of dietary Zn on high Cu intake in sheep
Journal Article
·
· J. Anim. Sci.; (United States)
OSTI ID:5017043
The objective was to determine whether high dietary levels of Zn will ameliorate or prevent chronic Cu toxicity in lambs fed a high Cu containing finishing diet. Four-month-old crossbred lambs were individually fed a pelleted diet of 35% cottonseed hulls, 5% alfalfa, 1.6% urea, 57.4% corn meal, vitamins A and D and minerals. The ration supplements and number of head per treatment were: group 1, none (4); group 2, 45 ppm Cu (5);group 3, 45 ppm Cu plus 250 ppm Zn (5), group 4, 45 ppm Cu plus 500 ppm Zn. The Cu and Zn supplements were CuSO/sub 4/ and ZnO. Plasma aspartate transaminase (AspT) activity, measured biweekly, was first elevated after 41 days feeding. Thereafter, in group 2, one lamb died and the AspT levels of the others gradually increased to a point where death from chronic Cu toxicity seemed imminent; the lambs in all groups were then slaughtered after 91 days feeding. Mean plasma AspT (SF units/ml) and liver Cu and Zn (..mu..g/g DM) at slaughter were, respectively: group 1, 65, 232 and 118; group 2, 308, 1074 and 135; group 3, 130, 705 and 139; group 4, 194, 1145 and 179. Neither Zn level reduced (P > .05) liver Cu; both reduced (P < .05) AspT activity late in the study, but not to control levels (P < .05). Thus, chronic Cu toxicity may be delayed, but not prevented, by high Zn levels.
- Research Organization:
- Dept. of Agriculture, Beltsville, MD
- OSTI ID:
- 5017043
- Journal Information:
- J. Anim. Sci.; (United States), Journal Name: J. Anim. Sci.; (United States) Vol. 43:1; ISSN JANSA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BODY
CHALCOGENIDES
COPPER
COPPER COMPOUNDS
COPPER SULFATES
DAMAGE
DIET
DIGESTIVE SYSTEM
DOMESTIC ANIMALS
ELEMENTS
ENZYME ACTIVITY
GLANDS
LIVER
MAMMALS
METALS
ORGANS
OXIDES
OXYGEN COMPOUNDS
RESPONSE MODIFYING FACTORS
RUMINANTS
SHEEP
STIMULATION
SULFATES
SULFUR COMPOUNDS
TOXICITY
TRANSITION ELEMENT COMPOUNDS
TRANSITION ELEMENTS
VERTEBRATES
ZINC
ZINC COMPOUNDS
ZINC OXIDES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BODY
CHALCOGENIDES
COPPER
COPPER COMPOUNDS
COPPER SULFATES
DAMAGE
DIET
DIGESTIVE SYSTEM
DOMESTIC ANIMALS
ELEMENTS
ENZYME ACTIVITY
GLANDS
LIVER
MAMMALS
METALS
ORGANS
OXIDES
OXYGEN COMPOUNDS
RESPONSE MODIFYING FACTORS
RUMINANTS
SHEEP
STIMULATION
SULFATES
SULFUR COMPOUNDS
TOXICITY
TRANSITION ELEMENT COMPOUNDS
TRANSITION ELEMENTS
VERTEBRATES
ZINC
ZINC COMPOUNDS
ZINC OXIDES