Immune function in aging atomic bomb survivors residing in the United States

Journal Article · Tue Nov 01 04:00:00 EST 1983 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3576223· OSTI ID:5016465

Bloom, E T ^[1]; Korn, E L; Takasugi, M; Toji, D S; Onari, K; Makinodan, T

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1. VA West Los Angeles Medical Center, Los Angeles, CA

Immunologic parameters were studied among survivors of the 1945 atomic bombs who now reside in the United States. Of all known survivors living in the US, about 40% (n = 189) participated in this study. Of those survivors on whom radiation exposure information was available (n = 168), 96% were exposed to less than 50 rad at the time of the bomb (ATB). Survivors were divided into two groups; those exposed to varying low doses of radiation (S/sub +/ group, exposed at less than or equal to 2500 m from the hypocenter) were compared with those exposed to 0 rad (S/sub 0/ group, exposed at > 2500 m from the hypocenter). Of the former group, 92% were exposed to less than 100 rad and 89% to less than 50 rad ATB. Cellular immune responses, including natural cell-mediated cytotoxicity (NCMC), interferon production, and the mitogenic response to PHA, tended to be higher among S/sub +/ individuals, although only the different for NCMC was statistically significant. This was suggestive of a trend which was consistent with the higher serum interferon levels and lower frequencies of detectable immune complexes and antimitochondrial antibodies among the S/sub +/ group, although these differences were not statistically significant.

• OSTI ID: 5016465
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 96:2; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

551000 -- Physiological Systems
560151* -- Radiation Effects on Animals-- Man
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
A-BOMB SURVIVORS
ANTIBODY FORMATION
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DATA
DELAYED RADIATION EFFECTS
EXPERIMENTAL DATA
GLOBULINS
HUMAN POPULATIONS
IMMUNITY
IMMUNOGLOBULINS
IMMUNOLOGY
INFORMATION
INTERFERON
NORTH AMERICA
NUMERICAL DATA
ORGANIC COMPOUNDS
POPULATIONS
PROTEINS
RADIATION EFFECTS
USA