Comparison of oral iodine-131-cellulose and indium-111-DTPA as tracers for colon transit scintigraphy: Analysis by colon activity profiles

Journal Article · Sun Sep 01 00:00:00 EDT 1991 · Journal of Nuclear Medicine; (United States)

OSTI ID:5013329

Smart, R C; McLean, R G; Gaston-Parry, D; Barbagallo, S; Bruck, C E; King, D W; Lubowski, D Z; Talley, N A ^[1]

---

1. Department of Nuclear Medicine, St. George Hospital, Sydney, NSW (Australia)

In 11 normal subjects and 11 patients with a clinical diagnosis of constipation, oral 131I-cellulose and 111In-DTPA were compared simultaneously as tracers for radionuclide colon transit scintigraphy. Visual assessment of the images revealed no differences between tracers. Quantitation was performed using total and segmental percent retention and the derived value of clearance half-time. In addition, profiles of the activity distribution along the length of the colon were generated and the mean position of the activity in the colon calculated. For all indices, the results were similar in both normal subjects and constipated patients when comparing tracers, although marked differences were present between normal subjects and constipated patients for each tracer. Indium-111-DTPA was easy to administer and dosimetry was more acceptable than for 131I-cellulose, especially in constipated patients. It is concluded that 111In-DTPA is the preferred tracer for oral colon transit scintigraphy.

• OSTI ID: 5013329
• Journal Information: Journal of Nuclear Medicine; (United States), Vol. 32:9; ISSN 0161-5505
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
DIGESTIVE SYSTEM DISEASES
DIAGNOSIS
LARGE INTESTINE
SCINTISCANNING
RADIOPHARMACEUTICALS
PERFORMANCE
CELLULOSE
COMPARATIVE EVALUATIONS
CONSTIPATION
DTPA
DYNAMIC FUNCTION STUDIES
EFFICIENCY
INDIUM 111
IODINE 131
ORAL ADMINISTRATION
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOHYDRATES
CARBOXYLIC ACIDS
CHELATING AGENTS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVALUATION
GASTROINTESTINAL TRACT
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
INTESTINES
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
POLYSACCHARIDES
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
SACCHARIDES
SYMPTOMS
550601* - Medicine- Unsealed Radionuclides in Diagnostics