Incidence and management of secondary malignancies in patients with retinoblastoma and Ewing's sarcoma
Journal Article
·
· Oncology (Williston Park, N.Y.); (United States)
OSTI ID:5011636
- Department of Radiation Oncology, Stanford University Medical Center, CA (United States)
Childhood cancer survivors at highest risk of developing a secondary malignancy are those with hereditary retinoblastoma. The majority of such secondary cancers will be sarcomas, most commonly of bone. One-third of these occur outside a typical radiation field, commonly in an extremity. Bone sarcoma is also the most commonly reported secondary cancer to develop among survivors of Ewing's sarcoma. In this group, radiation doses greater than 60 Gy as well as alkylating agent chemotherapy have been identified as contributors to the increased risk. The prognosis for patients with a secondary sarcoma has been poor, with few cures reported to date. However, an aggressive, combined modality approach, including radical resection, postoperative radiation, and adjuvant chemotherapy, may improve the survival rate.
- OSTI ID:
- 5011636
- Journal Information:
- Oncology (Williston Park, N.Y.); (United States), Journal Name: Oncology (Williston Park, N.Y.); (United States) Vol. 5:5; ISSN 0890-9091; ISSN OCLGE
- Country of Publication:
- United States
- Language:
- English
Similar Records
Risk Factors Associated With Secondary Sarcomas in Childhood Cancer Survivors: A Report From the Childhood Cancer Survivor Study
In vitro radiation studies on Ewing's sarcoma cell lines and human bone marrow: application to the clinical use of total body irradiation (TBI)
Long-term results in 144 localized Ewing's sarcoma patients treated with combined therapy
Journal Article
·
Sat Sep 01 00:00:00 EDT 2012
· International Journal of Radiation Oncology, Biology and Physics
·
OSTI ID:22149474
In vitro radiation studies on Ewing's sarcoma cell lines and human bone marrow: application to the clinical use of total body irradiation (TBI)
Journal Article
·
Sun Jul 01 00:00:00 EDT 1984
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
·
OSTI ID:6579365
Long-term results in 144 localized Ewing's sarcoma patients treated with combined therapy
Journal Article
·
Sat Apr 15 00:00:00 EDT 1989
· Cancer (Philadelphia); (United States)
·
OSTI ID:5988095
Related Subjects
560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE GROUPS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CHILDREN
DELAYED RADIATION EFFECTS
DISEASES
DOSES
EYES
FACE
HEAD
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
RADIATION DOSES
RADIATION EFFECTS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
SARCOMAS
SENSE ORGANS
SIDE EFFECTS
SKELETON
SURVIVAL CURVES
THERAPY
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE GROUPS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CHILDREN
DELAYED RADIATION EFFECTS
DISEASES
DOSES
EYES
FACE
HEAD
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
RADIATION DOSES
RADIATION EFFECTS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
SARCOMAS
SENSE ORGANS
SIDE EFFECTS
SKELETON
SURVIVAL CURVES
THERAPY