Thymic irradiation inhibits the rapid recovery of TH1 but not TH2-like functions of CD4+ T cells after total lymphoid irradiation

Journal Article · Tue Oct 15 04:00:00 EDT 1991 · Cellular Immunology; (United States)

DOI:https://doi.org/10.1016/0008-8749(91)90082-M· OSTI ID:5011403

Bass, H; Adkins, B; Strober, S ^[1]

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1. Department of Medicine, Stanford University School of Medicine, CA (United States)

Four to six weeks after total lymphoid irradiation (TLI), there is a selective deficit in the CD4+ T cells which secrete IL-2, proliferate in the MLR, and induce GVHD (Th1-like functions). A similar deficit in CD4+ T cells which secrete IL-4 and help antibody responses (Th2-like functions) is not observed. In the present study, shielding of the thymus with lead during TLI increased the Th1-like functions of CD4+ cells. Mice without thymus shields showed a marked selective reduction in the medullary stromal cells identified with the monoclonal antibody, MD1, and the severe reduction was prevented with thymus shields. Thus, shielding the thymus prevents the depletion of thymic medullary stromal cells and allows for a rapid recovery of Th1-like functions in the mouse spleen after TLI. Th2-like functions recover rapidly after TLI whether or not the thymus is irradiated.

• OSTI ID: 5011403
• Journal Information: Cellular Immunology; (United States), Journal Name: Cellular Immunology; (United States) Vol. 137:2; ISSN CLIMB; ISSN 0008-8749
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTIBODIES
ANTIBODY FORMATION
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL SHIELDING
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CELL PROLIFERATION
CONNECTIVE TISSUE CELLS
EXTERNAL IRRADIATION
GLOBULINS
GRAFT-HOST REACTION
GROWTH FACTORS
IMMUNITY
IMMUNOGLOBULINS
INHIBITION
IRRADIATION
LEUKOCYTES
LYMPHATIC SYSTEM
LYMPHOCYTES
LYMPHOKINES
MAMMALS
MATERIALS
MICE
MITOGENS
MONOCLONAL ANTIBODIES
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIATION EFFECTS
RODENTS
SECRETION
SHIELDING
SOMATIC CELLS
SPLEEN
THYMUS
VERTEBRATES
WHOLE-BODY IRRADIATION