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Scavenger receptor for malondialdehyde-modified high density lipoprotein on rat sinusoidal liver cells

Journal Article · · Biochem. Biophys. Res. Commun.; (United States)
; ; ;

The presence of a membrane-associated receptor which mediates endocytic uptake of malondialydehyde-modified high density lipoprotein (MDA-HDL) on sinusoidal liver cells is reported. Binding of (/sup 125/I)MDA-HDL to the cells was followed by internalization and degradation in lysosomes. The binding and lysomal degradation of (/sup 125/I)MDA-HDL were effectively inhibited by unlabeled MDA-HDL and acetyl-HDL. However, formaldehyde-treated serum albumin or low density lipoprotein modified either by acetylation or malondialdehyde, ligands known to undergo receptor-mediated endocytosis by sinusoidal liver cells, did not affect the binding of (/sup 175/I)MDA-HDL to the cells. These results indicate that a receptor for MDA-HDL is described as a distinct member among the scavenger receptors for chemically modified proteins.

Research Organization:
Kumamoto Univ. Medical School, Japan
OSTI ID:
5009170
Journal Information:
Biochem. Biophys. Res. Commun.; (United States), Journal Name: Biochem. Biophys. Res. Commun.; (United States) Vol. 137:1; ISSN BBRCA
Country of Publication:
United States
Language:
English

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Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ACETYLATION
ACYLATION
ALBUMINS
ALDEHYDES
ANIMAL CELLS
BETA DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
BIODEGRADATION
BLOOD SERUM
CARBOXYLIC ACIDS
CELL CONSTITUENTS
CELL MEMBRANES
CHEMICAL REACTIONS
DATA
DAYS LIVING RADIOISOTOPES
DECOMPOSITION
DICARBOXYLIC ACIDS
ELECTRON CAPTURE RADIOISOTOPES
EXPERIMENTAL DATA
INFORMATION
INHIBITION
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
LABELLED COMPOUNDS
LIGANDS
LIPIDS
LIPOPROTEINS
LIVER CELLS
LYSOSOMES
MALONIC ACID
MEMBRANE PROTEINS
MEMBRANES
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANOIDS
PROTEINS
RADIOISOTOPES
REACTION KINETICS
RECEPTORS
RESPONSE MODIFYING FACTORS
SOMATIC CELLS
TRACER TECHNIQUES