Left ventricular diastolic filling and its association with age
Journal Article
·
· Am. J. Cardiol.; (United States)
Thirty normal subjects, aged 22 to 80 years, were studied by radionuclide ventriculography to determine the age dependence of cardiac ventricular diastolic function and to evaluate the association of other factors with ventricular diastolic performance. A strong negative correlation was found between peak diastolic filling rate and age (r = -0.82, p less than 0.0001). Partial correlation analysis was used to factor out the strong age dependence and yielded additional significant correlations of peak filling rate with heart rate (r = 0.48, p less than 0.01) and time to peak filling rate (r = -0.48, p less than 0.01). Time to peak filling rate is also correlated with heart rate but not definitely with age. Analysis by multiple linear regression yields an equation predicting peak filling rate from age and heart rate. Thus, the rate of rapid diastolic filling declines markedly with age in normal subjects. The association of peak filling rate with age and with other factors indicates the need for careful consideration of these factors in the interpretation of scintigraphic findings in patients with heart disease.
- Research Organization:
- Washington Univ. School of Medicine, St. Louis, MO
- OSTI ID:
- 5008366
- Journal Information:
- Am. J. Cardiol.; (United States), Journal Name: Am. J. Cardiol.; (United States) Vol. 6; ISSN AJCDA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AGE DEPENDENCE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOMEDICAL RADIOGRAPHY
BLOOD FLOW
BODY
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DYNAMIC FUNCTION STUDIES
HEART
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MAN
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PRIMATES
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOLOGY
SCINTISCANNING
TECHNETIUM 99
TECHNETIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
62 RADIOLOGY AND NUCLEAR MEDICINE
AGE DEPENDENCE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOMEDICAL RADIOGRAPHY
BLOOD FLOW
BODY
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DYNAMIC FUNCTION STUDIES
HEART
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MAN
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PRIMATES
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOLOGY
SCINTISCANNING
TECHNETIUM 99
TECHNETIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES