Familial malignant melanoma

Journal Article · Fri Oct 10 04:00:00 EDT 1986 · JAMA, J. Am. Med. Assoc.; (United States)

DOI:https://doi.org/10.1001/jama.256.14.1915· OSTI ID:5007096

Kopf, A W; Hellman, L J; Rogers, G S; Gross, D F; Rigel, D S; Friedman, R J; Levenstein, M; Brown, J; Golomb, F M; Roses, D F; Gumport, S L

Characteristics associated with familial compared with nonfamilial malignant melanoma were assessed. These data were obtained from consecutive prospectively completed questionnaires on 1169 cases of cutaneous malignant melanoma. Of these, 69 patients indicated a positive family history for this cancer. Among the various clinical and histological variables compared, those that significantly correlated with the familial occurrence of malignant melanoma include younger age at first diagnosis, smaller diameter of the lesion, lower Clark level, decreased frequency of nonmelanoma skin cancer, and reduced prevalence of noncutaneous cancer. Increased awareness of malignant melanoma among family members could account for some of these observations. Identification of the familial variety of malignant melanoma has practical implications concerning early detection and prompt intervention.

• Research Organization: New York Univ. of School of Medicine, NY
• DOE Contract Number: AC02-76ER03077
• OSTI ID: 5007096
• Journal Information: JAMA, J. Am. Med. Assoc.; (United States), Journal Name: JAMA, J. Am. Med. Assoc.; (United States) Vol. 256:14; ISSN JAMAA
• Country of Publication: United States
• Language: English

Related Subjects

550900* -- Pathology
59 BASIC BIOLOGICAL SCIENCES
AGE GROUPS
BODY
CHILDREN
DISEASE INCIDENCE
DISEASES
EPIDEMIOLOGY
ETIOLOGY
HEREDITARY DISEASES
MELANOMAS
NEOPLASMS
ORGANS
PATIENTS
RISK ASSESSMENT
SKIN