Endosulfan and cholinergic (muscarinic) transmission: effect on electroencephalograms and (/sup 3/H)quinuclidinyl benzilate in pigeon brain

Journal Article · Fri Aug 01 00:00:00 EDT 1986 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/S0013-9351(86)80117-7· OSTI ID:5006598

Anand, M; Agrawal, A K; Gopal, K; Sur, R N; Seth, P K

Single exposure of endosulfan (5 mg/kg) to pigeons (Columbia livia) caused neuronal hyperexcitability as evidence by spike discharges of 200-500 ..mu..V in the electroencephalograms (EEG) from the telencephalon and hyperstriatum, but there was not effect on the ectostriatal area. Cholinergic (muscarinic) receptor binding study using (/sup 3/H)quinuclidinyl benzilate ((/sup 3/H)QNB) as a specific ligand indicated that a single exposure to 5 mg/kg of endosulfan caused a significant increase in (/sup 3/H)QNB binding to the striatal membrane. Behavior study further indicated that a single dose of 200 ..mu..g/kg of oxotremorine produced a significant induction in the tremor in endosulfan-pretreated pigeons. The results of this behavioral and biochemical study indicate the involvement of a cholinergic (muscarinic) transmitter system in endosulfan-induced neurotoxicity.

• Research Organization: Industrial Toxicology Research Centre, Lucknow, India
• OSTI ID: 5006598
• Journal Information: Environ. Res.; (United States), Vol. 40:2
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
CENTRAL NERVOUS SYSTEM
INJURIES
NEUROREGULATORS
BIOCHEMICAL REACTION KINETICS
PESTICIDES
TOXICITY
PIGEONS
BEHAVIOR
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIRDS
DRUGS
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
NERVOUS SYSTEM
REACTION KINETICS
VERTEBRATES
551001* - Physiological Systems- Tracer Techniques