Immunologic monitoring of patients with small cell anaplastic carcinoma who are treated with chemotherapy and radiotherapy
Journal Article
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
From January to October 1978 the diagnosis of small cell anaplastic carcinoma was made in 12 patients. Patients were treated with chemotherapy and radiotherapy and were followed for 13 months. Before treatment lymphocyte stimulation (L.S.) and blood T and B lymphocytes were within normal range. Positive skin tests were observed in patients who had a large weight loss. After treatment, the number of lymphocytes dropped, but the T/B radio did not change. T lymphocyte function was impaired (decrease of LS with phytohemagglutinine) but B lymphocyte function was normal (normal LS with Pockeweed Mitogen). The skin tests became negative after radiotherapy or when patients had a loss of body weight of more than 10%. In spite of its imprecision, skin tests appear to be the best to follow immunological status. More sophisticated tests gave no supplementary information. Immunological status could not be related to prognosis.
- Research Organization:
- Grenoble Univ., France
- OSTI ID:
- 5006243
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 6:8; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
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550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
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BIOLOGICAL EFFECTS
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IMMUNOLOGY
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NEOPLASMS
NUCLEAR MEDICINE
ORGANS
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BIOLOGICAL INDICATORS
BIOLOGICAL MATERIALS
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BLOOD CELLS
BODY
BODY FLUIDS
CARCINOMAS
CHEMOTHERAPY
CONNECTIVE TISSUE CELLS
DELAYED RADIATION EFFECTS
DIGESTIVE SYSTEM
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FRACTIONATED IRRADIATION
IMMUNOLOGY
IRRADIATION
LEUKOCYTES
LUNGS
LYMPHOCYTES
MATERIALS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATIENTS
RADIATION EFFECTS
RADIOLOGY
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SIDE EFFECTS
SKIN
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THERAPY