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Value of preoperative radiotherapy in operable mammary carcinoma

Conference · · Int. J. Radiat. Oncol., Biol. Phys.; (United States)
OSTI ID:5005819
 [1]; ; ; ; ; ; ;
  1. Radiumhemmet, Stockholm, Sweden
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In a randomized trial preoperative radiotherapy (4500 rad to the breast, the internal mammary, the supraclavicular and the axillary lymph node regions) was compared to radical mastectomy followed either by no further treatment or by postoperative radiotherapy. The total number of patients was 960; 356 of these had a follow-up time of more than five years. Both preoperative and postoperative irradiation increased the disease-free survival, compared to survival in patients who were treated only by surgery. The patients who were irradiated preoperatively had significantly better survival rates than the control patients (p = 0.05). Compared to patients who were treated with surgery only the survival improvement was even more certain (p = 0.03). Patients whose tumors were located in the inner half of the breast seemed to benefit more from preoperative or postoperative irradiation than those with lateral tumors. This could support the hypothesis of the value of adequate irradiation of the internal mammary nodes.
OSTI ID:
5005819
Conference Information:
Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Journal Volume: 6:3
Country of Publication:
United States
Language:
English

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Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOMAS
DATA
DISEASES
DOSES
EVALUATION
EXPERIMENTAL DATA
FEMALES
GLANDS
INFORMATION
MAMMALS
MAMMARY GLANDS
MAN
MEDICINE
NEOPLASMS
NUMERICAL DATA
ORGANS
PATIENTS
POST-IRRADIATION THERAPY
PRIMATES
RADIATION DOSES
RADIATION EFFECTS
SURGERY
SURVIVAL CURVES
THERAPY
VERTEBRATES
WOMEN