Secondary malignant giant-cell tumor of bone. Clinicopathological assessment of nineteen patients

Journal Article · Mon Sep 01 04:00:00 EDT 1986 · J. Bone Jt. Surg., Am. Vol.; (United States)

OSTI ID:5005084

Rock, M G; Sim, F H; Unni, K K; Witrak, G A; Frassica, F J; Schray, M F; Beabout, J W; Dahlin, D C

Twenty-six patients who had a malignant giant-cell tumor of bone--a sarcoma either juxtaposed to a zone of typical benign giant-cell tumor or occurring at the site of a previously documented benign giant-cell tumor--have been seen at the Mayo Clinic. Of the twenty-six tumors, nineteen were secondary to a previous attempt at local control of a benign giant-cell tumor. All but one of these nineteen patients with a secondary tumor had received therapeutic irradiation four to thirty-nine years earlier. The nature and duration of the symptoms and the sites of predilection of the malignant giant-cell tumors were the same as for benign giant-cell tumor. Fibrosarcoma occurred three times as frequently as osteosarcoma. The best results of treatment of the secondary sarcoma were obtained with early ablation.

• Research Organization: Mayo Clinic, Rochester, MN
• OSTI ID: 5005084
• Journal Information: J. Bone Jt. Surg., Am. Vol.; (United States), Journal Name: J. Bone Jt. Surg., Am. Vol.; (United States) Vol. 7; ISSN JBJSA
• Country of Publication: United States
• Language: English

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