1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridine (MPP/sup +/) cause rapid ATP depletion in isolated hepatocytes
Journal Article
·
· Biochem. Biophys. Res. Commun.; (United States)
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its oxidized metabolite 1-methyl-4-phenylpyridine (MPP/sup +/) produce a rapid depletion of intracellular ATP in isolated rat hepatocytes. This effect was dose-dependent and was consistently observed before the onset of toxicity. The monoamine oxidase inhibitor pargyline provide significant protection against MPTP-induced cell death and ATP loss, but had no effect with MPP/sup +/. Thus, ATP depletion may play a critical role in MPTP toxicity, possibly via the metabolic production of MPP/sup +/.
- Research Organization:
- Univ. of California, Berkeley
- OSTI ID:
- 5003039
- Journal Information:
- Biochem. Biophys. Res. Commun.; (United States), Journal Name: Biochem. Biophys. Res. Commun.; (United States) Vol. 137:1; ISSN BBRCA
- Country of Publication:
- United States
- Language:
- English
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Synthesis and biological activity of analogs of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its monoamine oxidase-derived metabolites
Journal Article
·
Mon May 15 00:00:00 EDT 1989
· Archives of Biochemistry and Biophysics; (USA)
·
OSTI ID:5405252
Entry of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine into the rat brain
Journal Article
·
Thu Jun 01 00:00:00 EDT 1989
· J. Pharmacol. Exp. Ther.; (United States)
·
OSTI ID:5878892
Synthesis and biological activity of analogs of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its monoamine oxidase-derived metabolites
Thesis/Dissertation
·
Sat Dec 31 23:00:00 EST 1988
·
OSTI ID:6531658
Related Subjects
560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINE OXIDASES
ANIMAL CELLS
ANIMALS
ATP
AZINES
BIOLOGICAL PATHWAYS
CELL KILLING
DATA
DOSE-RESPONSE RELATIONSHIPS
ENZYME INHIBITORS
ENZYMES
EXPERIMENTAL DATA
HETEROCYCLIC COMPOUNDS
INFORMATION
LIVER CELLS
MAMMALS
METABOLITES
NUCLEOTIDES
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXIDOREDUCTASES
PYRIDINES
RATS
RESPONSE MODIFYING FACTORS
RODENTS
SOMATIC CELLS
TOXICITY
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINE OXIDASES
ANIMAL CELLS
ANIMALS
ATP
AZINES
BIOLOGICAL PATHWAYS
CELL KILLING
DATA
DOSE-RESPONSE RELATIONSHIPS
ENZYME INHIBITORS
ENZYMES
EXPERIMENTAL DATA
HETEROCYCLIC COMPOUNDS
INFORMATION
LIVER CELLS
MAMMALS
METABOLITES
NUCLEOTIDES
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXIDOREDUCTASES
PYRIDINES
RATS
RESPONSE MODIFYING FACTORS
RODENTS
SOMATIC CELLS
TOXICITY
VERTEBRATES