Poly(ADP-ribose) biosynthesis and suicidal NAD+ depletion following carcinogen exposure of mammalian cells
Journal Article
·
· Biochem. Biophys. Res. Commun.; (United States)
Hepatocytes were found to be remarkably resistant to suicidal NAD+ depletion due to consumption for chromatin-associated poly(ADP-ribose) biosynthesis, which normally follows infliction of DNA damage in mammalian cells. N-methyl-N'-nitro-N-nitrosoguanidine treatment, which depleted NAD+ levels of confluent fibroblasts to about 40% of controls, did not reduce hepatocellular NAD+ pools, although poly(ADP-ribose) concentrations were concomitantly elevated by 21-fold. This differential behavior, demonstrable also with other carcinogens, can be attributed to the different NAD+ biosynthetic capacities of these cells.
- Research Organization:
- Univ. of Zurich, Switzerland
- OSTI ID:
- 5002806
- Journal Information:
- Biochem. Biophys. Res. Commun.; (United States), Journal Name: Biochem. Biophys. Res. Commun.; (United States) Vol. 3; ISSN BBRCA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Carcinogen-inflicted DNA damage causes a dramatic increase in the degradation of chromatin-bound poly(ADP-ribose) in mammalian cells
Poly(ADP-ribose) metabolism is altered in cells from a patient with glutamyl ribose-5-phosphate storage disease
Poly(ADP-ribose) synthesis following DNA damage in cells heterozygous or homozygous for the xeroderma pigmentosum genotype
Conference
·
Fri May 01 00:00:00 EDT 1987
· Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
·
OSTI ID:6176619
Poly(ADP-ribose) metabolism is altered in cells from a patient with glutamyl ribose-5-phosphate storage disease
Conference
·
Thu May 01 00:00:00 EDT 1986
· Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
·
OSTI ID:5204569
Poly(ADP-ribose) synthesis following DNA damage in cells heterozygous or homozygous for the xeroderma pigmentosum genotype
Journal Article
·
Sat Jan 24 23:00:00 EST 1981
· J. Biol. Chem.; (United States)
·
OSTI ID:6056192
Related Subjects
560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BIOSYNTHESIS
BODY
CARCINOGENS
COENZYMES
DIGESTIVE SYSTEM
DNA REPAIR
ESTERS
GLANDS
LIVER
MAMMALS
MICE
NAD
NITROSO COMPOUNDS
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RATS
RECOVERY
REPAIR
RODENTS
SULFURIC ACID ESTERS
SYNTHESIS
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BIOSYNTHESIS
BODY
CARCINOGENS
COENZYMES
DIGESTIVE SYSTEM
DNA REPAIR
ESTERS
GLANDS
LIVER
MAMMALS
MICE
NAD
NITROSO COMPOUNDS
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RATS
RECOVERY
REPAIR
RODENTS
SULFURIC ACID ESTERS
SYNTHESIS
VERTEBRATES