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Effect of transferrin saturation on internal iron exchange

Journal Article · · Proc. Soc. Exp. Biol. Med.; (United States)
; ; ;
Radioiron was introduced into the intestinal lumen to evaluate absorption, injected as nonviable red cells to evaluate reticuloendothelial (RE) processing of iron, and injected as hemoglobin to evaluate hepatocyte iron processing. Redistribution of iron through the plasma was evaluated in control animals and animals whose transferrin was saturated by iron infusion. Radioiron introduced into the lumen of the gut as ferrous sulfate and as transferrin-bound iron was absorbed about half as well in iron-infused animals, and absorbed iron was localized in the liver. The similar absorption of transferrin-bound iron suggested that absorption of ferrous iron occurred via the mucosal cell and did not enter by diffusion. The decrease in absorption was associated with an increase in mucosal iron and ferritin content produced by the iron infusion. An inverse relationship (r = -0.895) was shown between mucosal ferritin iron and absorption. When iron was injected as nonviable red cells, it was deposited predominantly in reticuloendothelial cells of the spleen. Return of this radioiron to the plasma was only 6% of that in control animals. While there was some movement of iron from spleen to liver, this could be accounted for by intravascular hemolysis. Injected hemoglobin tagged with radioiron was for the most part taken up and held by the liver. Some 13% initially localized in the marrow in iron-infused animals was shown to be storage iron unavailable for hemoglobin synthesis. These studies demonstrate the hepatic trapping of absorbed iron and the inability of either RE cell or hepatocyte to release iron in the transferrin-saturated animal.
Research Organization:
Univ. of Pavia, Italy
OSTI ID:
5002309
Journal Information:
Proc. Soc. Exp. Biol. Med.; (United States), Journal Name: Proc. Soc. Exp. Biol. Med.; (United States) Vol. 1; ISSN PSEBA
Country of Publication:
United States
Language:
English

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Related Subjects

551001 -- Physiological Systems-- Tracer Techniques
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ANIMAL TISSUES
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW
DIGESTIVE SYSTEM
ELEMENTS
ERYTHROCYTES
GLANDS
GLOBULINS
GLOBULINS-BETA
HEMATOPOIETIC SYSTEM
INTESTINAL ABSORPTION
IRON
IRON ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LIVER
MAMMALS
MATERIALS
METABOLISM
METALLOPROTEINS
METALS
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RATS
RETICULOENDOTHELIAL SYSTEM
RODENTS
SPLEEN
TISSUES
TRACER TECHNIQUES
TRANSFERRIN
TRANSITION ELEMENTS
UPTAKE
VERTEBRATES