Age-dependent inhibition of pentobarbital sleeping time by ozone in mice and rats

Journal Article · Mon Sep 01 00:00:00 EDT 1986 · J. Gerontol.; (United States)

DOI:https://doi.org/10.1093/geronj/41.5.587· OSTI ID:5002252

Canada, A T; Calabrese, E J; Leonard, D

The effect of age on the metabolism of pentobarbital in mice and rats was investigated following exposure to 0.3 ppm of ozone for 3.75 hr. Young animals were 2.5 months of age and the mature were 18 months. The pentobarbital sleeping time was significantly prolonged following the ozone exposure in both the mice and rats when compared with an air control. No ozone effect on sleeping time was found in the young animals. The results indicate that there may be an age-related sensitivity to the occurrence of ozone-related inhibition of pentobarbital metabolism.

• Research Organization: Duke Univ. Medical Center, Durham, NC
• OSTI ID: 5002252
• Journal Information: J. Gerontol.; (United States), Vol. 5
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
OZONE
BIOLOGICAL EFFECTS
SLEEP
INHIBITION
AGE DEPENDENCE
LIVER
MICE
NEMBUTAL
RATS
RESPONSE MODIFYING FACTORS
ANESTHETICS
ANIMALS
AZINES
BARBITURATES
BODY
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DIGESTIVE SYSTEM
DRUGS
GLANDS
HETEROCYCLIC COMPOUNDS
HYPNOTICS AND SEDATIVES
MAMMALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PYRIMIDINES
RODENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)