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Lifetime effects of intratracheally instilled nickel subsulfide on B6C3F/sub 1/ mice

Journal Article · · Environ. Res.; (United States)
OSTI ID:5001989
; ;
A nickel subsulfide (Ni/sub 3/S/sub 2/) lung tumor model for the study of metal carcinogenesis was evaluated using intratracheally dosed B6C3F/sub 1/ mice. A preliminary study of the survival of mice 14 days after a single intratracheal dose of Ni/sub 3/S/sub 2/ displayed an LD/sub 50/ of 4 mg/kg. A lifetime study was then initiated using five graded doses of Ni/sub 3/S/sub 2/ or saline alone, administered once a week for 4 weeks. Animals which survived more than 60 days after the final dose were evaluated by histopathology. The study was terminated 27 months after initiation when approx.50% of the control animals had died. There was no increase in neoplastic or non-neoplastic lesions observed in animals treated with Ni/sub 3/S/sub 2/ nor was there evidence of damage to the organs of the respiratory tract from this treatment. The lack of significant biological response appears to be the result of relatively low tolerated dose, efficient lung clearance, and repair of early lung lesions.
Research Organization:
Battelle Columbus Division, OH
OSTI ID:
5001989
Journal Information:
Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 40:2; ISSN ENVRA
Country of Publication:
United States
Language:
English

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Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL MODELS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CARCINOGEN SCREENING
CHALCOGENIDES
CLEARANCE
DATA
EXCRETION
EXPERIMENTAL DATA
INFORMATION
INTRATRACHEAL ADMINISTRATION
LUNG CLEARANCE
MAMMALS
MICE
MORTALITY
NICKEL COMPOUNDS
NICKEL SULFIDES
NUMERICAL DATA
RECOVERY
REPAIR
RODENTS
SCREENING
SULFIDES
SULFUR COMPOUNDS
SURVIVAL CURVES
TOLERANCE
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES