Chemoradiotherapy as initial management in patients with squamous cell carcinoma of the head and neck

Journal Article · Sun Jun 01 04:00:00 EDT 1986 · Cancer Treat. Rep.; (United States)

OSTI ID:5001658

Adelstein, D J; Sharan, V M; Earle, A S; Shah, A C; Vlastou, C; Haria, C D; Carter, S G; Damm, C; Hines, J D

Thirty-nine previously untreated or minimally treated patients with squamous cell carcinoma of the head and neck were entered onto a chemoradiotherapy protocol employing multiple courses of simultaneous radiation therapy, cisplatin, and a 4-day 5-FU infusion. Thirty-eight patients were evaluable for response and toxicity. Twenty-three patients underwent surgical resection midway through this therapy and 11 (48%) were pathologically free of disease. Thirty-five of the 38 patients (92%) were ultimately rendered disease-free by this combined modality protocol. Thirty-one patients remain disease-free, with a projected 2-year disease-free survival of 74%. Although the treatment-associated mucositis and myelo-suppression were significant, this chemoradiotherapeutic approach is promising and merits further study.

• Research Organization: Cleveland Metropolitan General Hospital, OH
• OSTI ID: 5001658
• Journal Information: Cancer Treat. Rep.; (United States), Journal Name: Cancer Treat. Rep.; (United States) Vol. 6; ISSN CTRRD
• Country of Publication: United States
• Language: English

Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BODY
BODY AREAS
CARCINOMAS
CHEMOTHERAPY
DISEASES
HEAD
MEDICINE
NECK
NEOPLASMS
NUCLEAR MEDICINE
PATIENTS
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SURVIVAL TIME
THERAPY