Study of the effects of lead and light on the retina
Thesis/Dissertation
·
OSTI ID:5001264
Lipid peroxidation is one of the mechanisms by which lead may produce toxic effects. Since the retina possesses characteristics which may cause it to be susceptible to lipid peroxidation, the effects of lead on the rabbit retina were investigated. Changes were found in several indicators of lipid peroxidation including malonaldehyde levels and extractable fluorescence. Histologic and ultrastructural evaluations showed accumulation of lipofuscin and disruption of retinal architecture. The effect of concurrent constant light was also tested and was found to be a modification of the effects produced by lead, probably mediated through a disruption of normal retinal physiology. A decrease in catalase activity was seen in the retinas of lead-exposed animals. Concurrent constant light treatment added to this inhibition. These findings suggest that lead can produce peroxidation effects in the eye and that the retina may be highly susceptible to peroxidated damage.
- Research Organization:
- Cincinnati Univ., OH (USA)
- OSTI ID:
- 5001264
- Country of Publication:
- United States
- Language:
- English
Similar Records
Pathology of the pigment epithelium and retina in rabbits poisoned with lead
Morphologic findings in the rabbit retina following irradiation with the free-running neodymium-YAG laser. Disruption of Bruch's membrane and its effect on the scarring process in the retina and choroid
Chronic lead administration in neonatal rats: electron microscopy of the retina
Journal Article
·
Thu Oct 31 23:00:00 EST 1974
· Am. J. Pathol.; (United States)
·
OSTI ID:5119492
Morphologic findings in the rabbit retina following irradiation with the free-running neodymium-YAG laser. Disruption of Bruch's membrane and its effect on the scarring process in the retina and choroid
Journal Article
·
Tue Jul 01 00:00:00 EDT 1986
· Arch. Ophthalmol. (Chicago); (United States)
·
OSTI ID:5113895
Chronic lead administration in neonatal rats: electron microscopy of the retina
Journal Article
·
Wed Feb 29 23:00:00 EST 1984
· J. Neuropathol. Exp. Neurol.; (United States)
·
OSTI ID:5928936
Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BODY
BODY AREAS
CATALASE
CHEMICAL REACTIONS
ELECTROMAGNETIC RADIATION
ENZYME ACTIVITY
ENZYMES
EYES
FACE
HEAD
LEAD COMPOUNDS
MAMMALS
ORGANS
OXIDATION
OXIDOREDUCTASES
PEROXIDASES
RABBITS
RADIATIONS
RETINA
SENSE ORGANS
VERTEBRATES
VISIBLE RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BODY
BODY AREAS
CATALASE
CHEMICAL REACTIONS
ELECTROMAGNETIC RADIATION
ENZYME ACTIVITY
ENZYMES
EYES
FACE
HEAD
LEAD COMPOUNDS
MAMMALS
ORGANS
OXIDATION
OXIDOREDUCTASES
PEROXIDASES
RABBITS
RADIATIONS
RETINA
SENSE ORGANS
VERTEBRATES
VISIBLE RADIATION