Relationship between bioconcentration in fish and steric factors of hydrophobic chemicals

Journal Article · Tue Jan 01 04:00:00 EST 1985 · Chemosphere; (United States)

DOI:https://doi.org/10.1016/0045-6535(85)90129-8· OSTI ID:5001124

Opperhulzen, A; Veide, E W; Gobas, F A.P.C.; Liem, D A.K.; Steen, J M.D.; Hutzinger, O

Most polychlorinated naphthalenes (PCN) accumulate rapidly according to their hydrophobicity. The uptake and elimination rate constants are comparable to those of chlorinated benzenes and biphenyls. For most PCN-congeners the resulting bioaccumulation factors show an increase with increasing hydrophobicity. For higher k/sub d. oct/-values (>10/sup 5/) however, no further increase of k/sub C/ is observed (K/sub C/ max = 3.5 10/sup 4/). For the hepta- and the octachloronaphthalenes no detectable concentrations are found in the fishes, although no restricted bio-availability could be expected. Based on these observations and on data obtained from the literature, a loss of membrane permeation is suggested for hydrophobic molecules with widths over 9.5 A. In addition a membrane permeation model, as part of the accumulation process of hydrophobic chemicals is proposed, which is based on diffusion and partition processes.

• Research Organization: Univ. of Amsterdam, Netherlands
• OSTI ID: 5001124
• Journal Information: Chemosphere; (United States), Journal Name: Chemosphere; (United States) Vol. 14:11-12; ISSN CMSHA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AQUATIC ORGANISMS
AROMATICS
BIOLOGICAL ACCUMULATION
CHLORINATED AROMATIC HYDROCARBONS
CONDENSED AROMATICS
DIFFUSION
FISHES
HALOGENATED AROMATIC HYDROCARBONS
HYDROCARBONS
KINETICS
MATHEMATICAL MODELS
MEMBRANE TRANSPORT
NAPHTHALENE
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
PERMEABILITY
VERTEBRATES