Generation of oxygen radicals by minerals and its correlation to cytotoxicity
- National Institute for Occupational Safety and Health, Morgantown, WV (United States)
Occupational exposure to mineral dust causes pneumoconiosis and other diseases. A cytotoxicity assay to predict the potential of minerals to cause disease would be of great value as a prevention strategy. This study compares the ability of several minerals to generate the more potent oxidizing agent, hydroxyl radical ({sm_bullet}OH), and their cytotoxicity and lipid peroxidation potentials. Crystalline silica, the most potent cytotoxic and pathogenic mineral studied, showed the least ability to generate {sm_bullet}OH radicals while inducing the maximal lipid peroxidation. Coal mine dust, showing the maximal ability to generate {sm_bullet}OH radicals, was the least cytotoxic in bioassays of toxicity and induction of lipid peroxidation. Based on these results, it would appear that the ability of minerals to induce lipid peroxidation provides a better correlation with known cytotoxicity and pathogenicity of minerals than does their ability to generate oxygen radicals. 21 refs., 8 figs., 1 tab.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 494240
- Report Number(s):
- CONF-9308288-; ISSN 0091-6765; TRN: 97:002099-0004
- Journal Information:
- Environmental Health Perspectives, Vol. 102, Issue Suppl.10; Conference: Conference on oxygen radicals and lung injury, Morgantown, WV (United States), 30 Aug - 2 Sep 1993; Other Information: PBD: Dec 1994
- Country of Publication:
- United States
- Language:
- English
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