The mouse mutation sarcosinemia (sar) maps to chromosome 2 in a region homologous to human 9q33-q34

Journal Article · Thu Aug 15 00:00:00 EDT 1996 · Genomics

DOI:https://doi.org/10.1006/geno.1996.0442· OSTI ID:484342

Brunialti, A L.B.; Guenet, J L ^[1]; Harding, C O; Wolff, J A ^[2]

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1. Institut Pasteur a Paris (France)
2. Univ. of Wisconsin, Madison, WI (United States)

The autosomal recessive mouse mutation sarcosinemia (sar), which was discovered segregating in the progeny of a male whose premeiotic germ cells had been treated with the mutagen ethylnitrosourea, is characterized by a deficiency in sarcosine dehydrogenase activity. Using an intersubspecific cross, we mapped the sar locus to mouse chromosome 2, approximately 15-18 cM from the centromere. The genetic localization of this locus in the mouse allows the identification of a candidate region in human (9q33-q34) where the homologous disease should map. 15 refs., 2 figs.

• OSTI ID: 484342
• Journal Information: Genomics, Journal Name: Genomics Journal Issue: 1 Vol. 36; ISSN 0888-7543; ISSN GNMCEP
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
AMINO ACIDS
BIOLOGICAL MODELS
CHROMOSOMES
ELECTROPHORESIS
ENZYME ACTIVITY
GENE AMPLIFICATION
GENE MUTATIONS
GENES
GENETIC EFFECTS
GENETIC MAPPING
GERM CELLS
HEREDITARY DISEASES
HUMAN CHROMOSOME 9
HYBRIDIZATION
METABOLIC DISEASES
METABOLISM
MICE
MUTAGENS
OXIDOREDUCTASES
RECESSIVE MUTATIONS
SARCOSINE