Assignment of human protein phosphatase 2A regulatory subunit genes B56{alpha}, B56{beta}, B56{gamma}, B56{delta}, and B56{epsilon} (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.1 {r_arrow} p12
- Univ. of Utah School of Medicine, Salt Lake City, UT (United States)
The activity of the major intracellular protein phosphatase, protein phosphatase 2A WPM, is determined by the nature of the associated regulatory subunit. A new family of human PP2A regulatory subunits has recently been identified. Three of these subunits, B56{beta}, B56{delta}, and B56{epsilon}, are most highly expressed in brain, while the B56{alpha} and B56{gamma} isoforms are highly expressed in cardiac and skeletal muscle. Genes PPP2R5A-PPP2R5E encoding the phosphatase regulatory proteins B56{alpha}, B56{beta}, B56{gamma}, B56{delta}, and B56{epsilon} have now been mapped by fluorescence in situ hybridization to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2-p12, respectively. 16 refs., 1 fig.
- OSTI ID:
- 484338
- Journal Information:
- Genomics, Journal Name: Genomics Journal Issue: 1 Vol. 36; ISSN 0888-7543; ISSN GNMCEP
- Country of Publication:
- United States
- Language:
- English
Similar Records
Structural and Biochemical Insights into the Regulation of Protein Phosphatase 2A by Small t Antigen of SV40
Structural Mechanism of Demethylation and Inactivation of Protein Phosphatase 2A
Related Subjects
BASIC STUDIES
BIOLOGICAL MARKERS
BRAIN
DNA HYBRIDIZATION
DNA-CLONING
FLUORESCENCE
GENE MUTATIONS
GENE REGULATION
GENETIC MAPPING
HEREDITARY DISEASES
HUMAN CHROMOSOME 1
HUMAN CHROMOSOME 3
HUMAN CHROMOSOME 6
HUMAN CHROMOSOME 7
HUMAN CHROMOSOMES
MAN
MUSCLES
PHOSPHATASES
PHOSPHORYLATION
PROTEINS
SPLICING
TISSUE DISTRIBUTION