A transcription map of the major histocompatibility complex (MHC) Class I region
- Yale Univ. School of Medicine, New Haven, CT (United States); and others
We have applied cDNA hybridization selection to nine YACs spanning 3 Mb of genomic DNA from a region centromeric to HLA-A to the histone cluster that lies telomeric to the human major histocompatibility complex (MHC). In addition to Class I genes and pseudogenes, we describe over 63 genes and 23 additional expressed sequence tags distributed throughout the region. Many of the full-length genes belong to gene families. Prominent among these are a group of genes encoding proteins showing homology to the carboxyl-terminal sequences of butyrophilin and an additional group of zinc finger genes. We also detected several previously undefined genes that are specifically expressed in cells of the immune system, indicating a more complex role of the MHC in the immune response than has been appreciated. 102 refs., 2 figs., 3 tabs.
- OSTI ID:
- 484327
- Journal Information:
- Genomics, Journal Name: Genomics Journal Issue: 1 Vol. 36; ISSN 0888-7543; ISSN GNMCEP
- Country of Publication:
- United States
- Language:
- English
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Mapping and characterization of non-HLA multigene assemblages in the human MHC class I region
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Related Subjects
BASIC STUDIES
ANTIGENS
B CODES
BIOLOGICAL EVOLUTION
CHROMOSOMAL ABERRATIONS
CONTIGS
DNA HYBRIDIZATION
DNA SEQUENCING
DNA-CLONING
FLUORESCENCE
GENE REGULATION
GENES
GENETIC MAPPING
HEREDITARY DISEASES
HISTOCOMPATIBILITY COMPLEX
HUMAN CHROMOSOME 6
IMMUNE REACTIONS
MAN
NUCLEOTIDES
POLYMERASE CHAIN REACTION
PROTEINS
STRUCTURE-ACTIVITY RELATIONSHIPS
TRANSCRIPTION