A transcription map of the major histocompatibility complex (MHC) Class I region

Journal Article · Thu Aug 15 00:00:00 EDT 1996 · Genomics

DOI:https://doi.org/10.1006/geno.1996.0427· OSTI ID:484327

Gruen, J R; Nalabolu, S R; Chu, T W ^[1]

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1. Yale Univ. School of Medicine, New Haven, CT (United States); and others

We have applied cDNA hybridization selection to nine YACs spanning 3 Mb of genomic DNA from a region centromeric to HLA-A to the histone cluster that lies telomeric to the human major histocompatibility complex (MHC). In addition to Class I genes and pseudogenes, we describe over 63 genes and 23 additional expressed sequence tags distributed throughout the region. Many of the full-length genes belong to gene families. Prominent among these are a group of genes encoding proteins showing homology to the carboxyl-terminal sequences of butyrophilin and an additional group of zinc finger genes. We also detected several previously undefined genes that are specifically expressed in cells of the immune system, indicating a more complex role of the MHC in the immune response than has been appreciated. 102 refs., 2 figs., 3 tabs.

• OSTI ID: 484327
• Journal Information: Genomics, Vol. 36, Issue 1; Other Information: PBD: 15 Aug 1996
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
GENES
TRANSCRIPTION
DNA SEQUENCING
GENE REGULATION
GENETIC MAPPING
DNA-CLONING
HISTOCOMPATIBILITY COMPLEX
HUMAN CHROMOSOME 6
BIOLOGICAL EVOLUTION
CHROMOSOMAL ABERRATIONS
STRUCTURE-ACTIVITY RELATIONSHIPS
B CODES
MAN
IMMUNE REACTIONS
HEREDITARY DISEASES
DNA HYBRIDIZATION
PROTEINS
ANTIGENS
NUCLEOTIDES
FLUORESCENCE
CONTIGS
POLYMERASE CHAIN REACTION