The inhibition of DNA synthesis by calf-thymus polymerase by X-irradiation of the primer DNA
Journal Article
·
· Biochemical and Biophysical Research Communications
Studies were made to determine whether or not DNA damaged by x irradiation may be easily replicated by the DNA synthetic mechanism. It was found that the synthesis of new material is strongly inhibited by large doses of x rays, and that within the experimental error, there is no great difference in the amounts of incorporation of d-TMP and d-CMP at any dose level that was examined. The results emphasize that the system used for assaying the effects of irradiation may greatly modify the results obtained.
- Research Organization:
- Yale Univ., New Haven
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-15-029014
- OSTI ID:
- 4843061
- Journal Information:
- Biochemical and Biophysical Research Communications, Vol. 5, Issue 6; Other Information: Orig. Receipt Date: 31-DEC-61; ISSN 0006-291X
- Publisher:
- Elsevier
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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OSTI ID:4843061