STUDIES OF STABLE IODINE METABOLISM AS A GUIDE TO THE INTERPRETATION OF RADIOIODINE TESTS

Journal Article · Tue Aug 01 04:00:00 EDT 1961 · Acta Endocrinologica (Denmark)

DOI:https://doi.org/10.1530/acta.0.0370597· OSTI ID:4839341

Koutras, D A; Alexander, W D; Buchanan, W W; Crooks, J; Wayne, E J

The significance of the size of the iodine pools in which the radioiodine is diluted in the thyroid is analyzed, and it is shown that there is a danger in interpreting radioiodine tests in isolation. The uptake of I/sup 131/ is inversely related to the extrathyroidal inorganic icdine pool, and the PBI/ sup 131/ is inversely related to the intrathyroidal iodine pool. Both these pools may be diminished in euthyroid persons and thus a high uptake of I/sup 131/ may be associated with a high PBI/sup 131/ and so lead to false diagnostic conclusions. In order to avoid diagnostic errors, standard I/sup 131/ tests should never be reported without some knowledge of relevant clinical features, for example, whether there is the possibility of prolonged iodine deficiency, of previous treatment, of Hashimoto's disease, or of dyshormonogenesis. In this way due weight can be given to factors which increase or decrease the iodine pools of the body and discrepancies between the clinical picture and radioiodine tests become obvious. More specific investigations can then be undertaken in appropriate cases. (auth)

• Research Organization: Western Infirmary, Glasgow
• Sponsoring Organization: USDOE
• NSA Number: NSA-15-027375
• OSTI ID: 4839341
• Journal Information: Acta Endocrinologica (Denmark), Journal Name: Acta Endocrinologica (Denmark) Vol. Vol: 37; ISSN ACENA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
DISEASES
GLANDS
HORMONES
IODINE
IODINE 131
MAN
MEDICINE
METABOLISM
THYROID