EFFECT OF X-RAY RADIATION ON GLUTATHIONE METABOLISM

Journal Article · Fri Jan 01 04:00:00 EST 1960 · Nippon Igaku Hoshasen Gakkai Zasshi (Japan)

OSTI ID:4839339

Kitamura, Y

Glutathione in the liver, muscles, and blcod of rabbits showed a noticeable decrease. A marked decrease of the liver glutathione was seen when a single dose of 4000 r was applied to the liver or 1000 r to the whole body. The same effect was seen in 6000 r of fractioned irradiation to the liver, or 2000 r of fractioned whole-body irradiation. No definite change in muscular glutathione was found after a single dose of 4000 r to the liver, but a moderate decrease of glutathione was observed after a single dose of 1000 r whole-body, 6000 r of fractioned irradiation to the liver, and 2000 r of fractioned whole-body irradiation. The blood glutathione decreased markedly after a single dose of 4000 r to the liver or a single dose of 6000 r whole-body, and fractionated irradiation totaling 6000 r to the liver and 1000 r whole-body. As counter- measures against injury to the glutathione metabolism system from the x irradiation to the liver, the prescription of L-methionine or glucuronic acid was shown to be the most effective with vit. B/sub 12/ next, while no effect of glucose and vit. B/sub 1/ was confirmed. The blocd glutathione of patients who were treated with a series of deep therapy was found to have diminished noticeably after x irradiation of 7000 r to 12000 r. (Abstr. Japan Med., 1: No. 10, 1961)

• Research Organization: Kyoto Univ.
• NSA Number: NSA-15-027387
• OSTI ID: 4839339
• Journal Information: Nippon Igaku Hoshasen Gakkai Zasshi (Japan), Journal Name: Nippon Igaku Hoshasen Gakkai Zasshi (Japan) Vol. Vol: 19; ISSN NHGZA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AMINO ACIDS
BIOLOGY AND MEDICINE
BLOOD
DISEASES
GLUTATHION
LIVER
MAN
METABOLISM
MUSCLES
QUANTITY RATIO
RABBITS
RADIATION DOSES
RADIATION EFFECTS
VITAMIN B-12
VITAMINS
X RADIATION