THE GENERAL PHARMACOLOGY OF THE HEAVY METALS
A discussion of predominantly theoretical aspects of metal poisoning is presented. Heavy metals are capable of combining with a wide variety of organic molecules. The heavy metal binding was found to occur simultaneously at sensitive and insensitive sites. This diversion of the metals to insensitive sites protects the cell to some extent against the toxic action of metals, but at the same time tends to obscure the relation between metal binding and pharmacological response. The interactions of heavy metals with simple molecules, proteins, enzymes, cells, organs, and animals are reviewed. The responses of biological systems to heavy metals were considered in terms of inferences that could be made concerning the site of the original chemical insult. A listing and discussion of the most commonly seen responses are given. (M.C.G.)
- Research Organization:
- Physiologisches Universitatsinstitut, Hamburg; Univ. of Rochester, N.Y.
- NSA Number:
- NSA-15-027388
- OSTI ID:
- 4839338
- Journal Information:
- Pharmacol. Revs., Vol. Vol: 13; Other Information: Orig. Receipt Date: 31-DEC-61
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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