THE INCORPORATION OF COPPER INTO CERULOPLASMIN IN VIVO: STUDIES WITH COPPER$sup 64$ AND COPPER$sup 6$$sup 7$
The hypothesis that ceruloplasmin exchanges its copper for ionic copper in vivo was tested, by means of ceruloplasmin labeled with copper-64 and copper- 67, in two patients with Wilson's disease and in two control subjects. No indication of exchange was found in any of three different experiments. It appears that copper is incorporated into the ceruloplasmin molecule in vivo only at the time of synthesis of the protein and not through exchange. A corollary of these results is that copper is a lifelong label of a ceruloplasmin molecule so that radioactive copper may be used for the determination of the turnover of ceruloplasmin and ceruloplasmin copper. The amount of copper incorporated daily into ceruloplasmin in a control subject corresponds closely to the amount of copper absorbed from the dietary intake. (auth)
- Research Organization:
- Albert Einstein Coll. of Medicine, New York, N.Y.; Bronx Municipal Hospital Center, New York, N.Y.; and Brookhaven National Lab., Upton, N.Y.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-15-031969
- OSTI ID:
- 4838832
- Journal Information:
- J. Clin. Invest, Vol. Vol: 40; Other Information: Orig. Receipt Date: 31-DEC-61
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
Similar Records
Metabolic model and dosimetric data for copper
Induction of ceruloplasmin synthesis by interleukin-1 in copper deficient and copper sufficient rats