STEREOCHEMICAL RELATIONSHIPS IN THE TRICARBOXYLIC ACID CYCLE: MECHANISM OF REACTIONS INVOLVING REVERSIBLE FORMATION OF CARBON-CARBON UNSATURATIONS

Journal Article · Fri Nov 25 04:00:00 EST 1960 · Annals of the New York Academy of Sciences (U.S.)

DOI:https://doi.org/10.1111/j.1749-6632.1960.tb39102.x· OSTI ID:4837917

Englard, S

Some observations on the reactions within the tricarboxylic acid cycle involving the reversible formation of carbon--carbon unsaturations are reviewed, and the results of a study on an anaerobic exchange of deuterium from the medium into succinate, as catalyzed by heart particle succinic oxidase preparations, are discussed in terms of the stereochemistry of the succinic dehydrogenase reaction. The stereospecific nature of the reversible hydrations of fumarate and cis- aconitate are described, and theoretical implications as regards the mechanism of the enzymatically catalyzed reactions are considered. Evidence is also presented that establishes the configuration of the product of the stereospecific enzymatic hydration of fumarate in D/sub 2/0 in relation to the stereospecificity of the aconitase-catalyzed reaction. The consequences of the configurational interrelationship are shown to provide evidence for a trans fumarase-catalyzed addition reaction. (P. C. H.)

• Research Organization: Yeshiva Univ., New York
• Sponsoring Organization: USDOE
• NSA Number: NSA-15-028954
• OSTI ID: 4837917
• Journal Information: Annals of the New York Academy of Sciences (U.S.), Journal Name: Annals of the New York Academy of Sciences (U.S.) Vol. Vol: 84; ISSN ANYAA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOCHEMISTRY
BIOLOGY AND MEDICINE
CATALYSIS
ENZYMES
HEART
HEAVY WATER