STUDIES ON THE PATHOGENESIS OF MENINGITIS. I. INTRATHECAL INFECTION
Meningitis was produced in dogs by inoculation with 10/sup 3/10/sup 6/ type III pneumococci via the subarachnoid space. This produced an infection lasting 48-96 hrs and characterized by cerebrospinal fluid (CSF) changes, including an increase of leukocytes and bacteria and a decrease in glucose concentration. This concentration was inversely related to the cell and bacteria counts of CSF. Pretreatment for 5 dogs with prednisolone did not alter the course of infection. When leukopenia was produced by 450 r whole-body irradiation, the number of inflammatory cells in the CSF was reduced in infected animals and survival was prolonged. This indicates that exudation into the subarachnoid space may have a harmful effect on the ventricular cavities where it may cause hydrocephalus. (H.H.D.)
- Research Organization:
- Johns Hopkins Univ., Baltimore, MD (United States)
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-16-020094
- OSTI ID:
- 4829400
- Journal Information:
- Journal of Clinical Investigation (U.S.), Vol. Vol: 41; Other Information: Orig. Receipt Date: 31-DEC-62
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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