Effect of ozone on respiratory responses in subjects with asthma

Journal Article · Wed Mar 01 04:00:00 EST 1995 · Environmental Health Perspectives

DOI:https://doi.org/10.1289/ehp.95103s2103· OSTI ID:482242

Koenig, J Q ^[1]

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1. Univ. of Washington, Seattle, WA (United States)

In the process of understanding the respiratory effects of individual air pollutants, it is useful to consider which populations seem to be most susceptible to the exposures. Ozone is the most ubiquitous air pollutant in the United States, and there is great interest in the extent of susceptibility to this air pollutant. This review presents evidence that individuals with asthma are more susceptible to adverse respiratory effects from ozone exposure than are nonasthmatic individuals under similar circumstances. In studies comparing patients with asthma to nonasthmatic subjects, research has shown increased pulmonary-function decrements, an increased frequency of bronchial hyperresponsiveness in ozone responders, increased signs of upper airway inflammation after ozone exposure, and an increased response to inhaled sulfur dioxide or allergen in the subjects with asthma. Subjects with asthma are indeed a population susceptible to the inhaled effects of ozone. These data need to be considered by regulators who are charged with setting air quality standards to protect even the most susceptible members of the population. They also underline the importance of strategies to reduce human exposure to ambient ozone. 16 refs., 1 fig.

• Sponsoring Organization: USDOE
• OSTI ID: 482242
• Report Number(s): CONF-9308287--
• Journal Information: Environmental Health Perspectives, Journal Name: Environmental Health Perspectives Journal Issue: Suppl.2 Vol. 103; ISSN 0091-6765; ISSN EVHPAZ
• Country of Publication: United States
• Language: English

Related Subjects

54 ENVIRONMENTAL SCIENCES
56 BIOLOGY AND MEDICINE
APPLIED STUDIES
AIR POLLUTION
AIR QUALITY
ASTHMA
BIOLOGICAL EFFECTS
INFLAMMATION
OZONE
RESPIRATORY SYSTEM DISEASES
SULFUR DIOXIDE