THE INFLUENCE OF X-RAY IRRADIATION UPON IMMUNITY TO THE CAUSATIVE ORGANISMS OF GAS-GANGRENE AND TETANUS
Exposure of guinea pigs to x rays of 400 r after active immunization with the toxoids of the causative organisms of gas-gangrene and tetanus led to a certain decrease in the antitoxin titre to all tyPes of antigens. The most considerable decrease in the antitoxin titre after irradiation was found in the sera of animals immunized with Cl.perfringens toxoid. The antitoxin titre decreased already after one day to 1/6th of the titre found in animals not exposed to radiation, The smallest decrease in antitoxin tltre was found in animals immunized with tetanus toxoid. Prolongation of the period elapsed after the radiation to 5 days did not reveal a further decrease in the antitoxin titres found in the sera of the immunized animals. A certain discrepancy was observed between the antitoxin titre of immunized animals exposed to radiation and their resistance to infection with the corresponding bacterial species: notwithstanding the high antitoxin tltre, the immunity after irradiation proved to be completely suppressed. The susceptibility of immunized animals to the causative organisms of gas-gangrene and tetanus decreased considerably after exposure to radiation and approached the susceptibillty of unimmunized animals, (auth)
- Research Organization:
- Originating Research Org. not identified
- NSA Number:
- NSA-16-007459
- OSTI ID:
- 4811796
- Journal Information:
- J. Microbiol., Epidemiol. Immunobiol. (U.S.S.R.) (English Translation), Vol. Vol: 32; Other Information: Orig. Receipt Date: 31-DEC-62
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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