LOW LEVELS OF X-IRRADIATION AND THE EARLY MAMMALIAN EMBRYO
Newly fertilized eggs of mice or the l-2 stage (at 24 hr) were x irradiated to low levels of 5 and 15 r, and the embryos and fetuses examined for sequelae. The percentage of early deaths and resorptions was increased over the controls to l9% among those irradiated before cleavage and to 9% among those irradiated during the first cleavage. Exencephaly (brain hernia) was found following only l5 r at both 0.5 and l.5 days post conception. Even after 5-r exposure there was some evidence of delay in the early cleavages and an increase in the percentage of early abnormals, cytologically determined. Some of the cytologic effects of x rays on the early embryo were: fragmentation, separation of blastomeres, elimination of protoplasm as blebs, elimination of one or both pronuclei, pyknosis of the nuclei, swelling, vacuolization, hyperchromaticity, and staining evidence of phase degeneration. (P.C.H.)
- Research Organization:
- Columbia Univ., New York
- NSA Number:
- NSA-16-009855
- OSTI ID:
- 4810916
- Journal Information:
- Am. J. Roentgenol., Radium Therapy Nuclear Med., Vol. Vol: 78; Other Information: Orig. Receipt Date: 31-DEC-62
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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