Thyroid Nodules Occurring Late After Treatment of Thyrotoxicosis with Radioiodine

Journal Article · Mon Jan 01 04:00:00 EST 1962 · Journal of Clinical Endocrinology and Metabolism

DOI:https://doi.org/10.1210/jcem-22-1-8· OSTI ID:4804119

SHELINE, GLENN E.; LINDSAY, STUART; McCORMACK, KENNETH R.; GALANTE, MAURICE

Among 256 patients with toxic diffuse goiter treated with adioiodine between 1946 and 1953, there were 8 patients in whom thyroid nodules developed between 5 and 14 years after the I¹³¹ therapy. Thyroidectomy in each of the 8 pa tients showed multiple nodules as well as effects attributable to irradiation. The frequency of occurrence of the late nodules was much higher in the younger patients, the highest freqddency being in those less than 20 years of age at the time of treatment. These nodules appeared to originate in hyperplastic regenerating areas of thyroid epithelium and were thought to be due to a stimulatory effect of thyrotropin acting on thyroid tissue still capable of proliferating despite injury by irradiation. Development of the thyroid nodules or adenomas in the 8 patients closely paralleled the development of nodules as described in irradiated rat thyroids. Except for a single inxasive adenoma in l patient, there was no evidence of malignancy in these human thyroid glands.

• Research Organization: Univ. of California, San Francisco
• Sponsoring Organization: USDOE
• NSA Number: NSA-16-006331
• OSTI ID: 4804119
• Journal Information: Journal of Clinical Endocrinology and Metabolism, Journal Name: Journal of Clinical Endocrinology and Metabolism Journal Issue: 1 Vol. 22; ISSN 0021-972X
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CANCER
DISEASES
IODINE 131
MAN
RADIATION INJURIES
RADIOTHERAPY
RATS
REGENERATION
SURGERY
THYROID
TISSUES
TUMORS